We are pleased to anounce you about our little stock update with HGH.Read More »
The Post Cycle Therapy category has been updated with HCG Pregnyl Organon and is available for $29 per 1 amp + the solvent. HCG Pregnyl is the liquid, purified prescription form of human chorionic gonadotropin (HCG). Pregnyl contains the luteinizing hormone and the follicle stimulating hormone.Read More »
New Geneza Pharmaceuticals bodybuilding steroids cycles are available for sale on Body-Pharm.net. Buy most wanted injectable Geneza steroids like: GP Andromix, GP M.D., GP Ment, GP Test U500) and oral Geneza Pharm steroids as: GP Bolasterone, GP Cheque Drops, GP MHN and many more.Read More »
We are pleased to announce you the availability of a new steroid Brand on our site- Dragon Pharma. Dragon Pharma is a relatively new manufacturer brand but has already gained its great reputation of combining high quality products with modern and innovative technology.Read More »
We are very pleased to announce that almost all the products from Sciroxx manufacturer are back in stock. Please check the available list of Sciroxx steroids accurately as most of their prices have been changed. It is our pleasure also to include to our steroid pharmacy a new Sciroxx item- Hexadex 450Read More »
It is our pleasure to announce that due to winter holidays BodyPharm.Net has decided to launch Christmas and New Year discounts, thus starting from November 30 up to 10th of January all the available products from our online bodybuilding shop are discounted with 10%.Read More »
Dear customers, bodybuilders and steroid users! We are glad to present you a new brand named Kalpa Pharmaceuticals. BodyPharm.net is their official reseller and you may check this information on Kalpa Pharmaceuticals official website. All Kalpa Pharmaceuticals products are being taken directly from manufacturer at the most convenient prices.Read More »
Before buying and using steroids it is very important to know the exact steroid benefits, but also to be aware of their side effects. BodyPharm.biz encourages you to find more information about anabolic steroids on specialized bodybuilding forums and only then make a purchase.
Attention for first time steroid users! You must be over 21 years old you must know whether or not internet purchases of drugs in your area are prohibited under local laws.
Thus being said, Bodypharm.biz welcomes you on this online platform of body building steroids and guarantees the safest delivery. Please remember that there is no need for prescription when purchasing steroids online from Body Pharm.biz. We sell only legal steroids from trusted sources.
To strengthen the anabolic properties of testosterone, more than 100 synthetic steroid derivatives have been described for human purposes. The anabolic effect promotes protein synthesis, muscle growth and erythropoiesis. In clinical practice, substances with anabolic effect are needed to overcome various catabolic states. However, none of these compounds are devoid of androgenicity. Androgenic and anabolic properties of anabolic steroids cannot be totally separated. Therefore, it is more appropriate to use the term anabolic androgenic steroids (AAS).
Testosterone and its derivatives are well absorbed from the gastrointestinal tract but are rapidly metabolized during hepatic Þ rst-pass metabolism without reaching systemic circulation. Testosterone is inactivated primarily by the cytochrome P450 hepatic isoenzyme. To increase systemic availability, AAS are modified as injectable 17β-esters or orally administered 17α-alkylated steroids. Orally administered testesterone undecanoate also avoids hepatic metabolism because it is absorbed from the alimentary canal through the lymphatic system.
After absorption from the gastrointestinal tract during hepatic first-pass metabolism, testosterone and AAS undergo biotransformation and are partly excreted via bile to the faeces. Testosterone in systemic circulation is also prone to metabolism in the liver, and once excreted, the steroid can be reabsorbed from the gastrointestinal tract. In peripheral tissues, testosterone is susceptible to glucuronization to androsterone and etiocholanolone, two major metabolites of testosterone, which are excreted to urine.
In vivo, different AAS are also potential targets for aromatization and reduction. Since the AAS molecule is susceptible to such enzymatic conversion, it possesses various biological properties.
The effects of AAS on genes and consecutive gene expression are poorly understood. Recently, human myostatin has been cloned and is considered to be a negative regulator of muscle growth. Basaria et al. (2001) speculated that AAS might act by inß uencing myostatin concentration. Further, all tissues are susceptible to androgen action. No tissues are devoid of androgen receptors, and all androgen receptors distributed throughout the body possess the same binding affinity for a particular steroid. Receptor-binding studies have not demonstrated marked differences between AAS in receptor-binding affinity. Young adolescents are more susceptible to androgen action of AAS because they possess a higher number of cytosol androgen receptors. Even with the biologically active unbound fraction of testosterone in circulation, androgen receptor sites are already saturated in striated muscles
Supraphysiological doses of AAS induce gain in muscle size and strength, even without concomitant exercise. At a supraphysiological dosage, AAS interacts with various receptors, including progesterone, estrogen, and mineralo- and glucocorticoid receptors. Supraphysiological doses of AAS have been speculated to mediate their anabolic action through interaction with glucocorticoid receptors by preventing glucocorticoids catabolic effect. Testosterone has in fact been shown to have a high affinity for glucocorticoid receptors and in vivo it acts as an antagonist to endogenous circulating glucocorticoids.
AAS lower the levels of certain hormone-binding proteins in circulation. Thyroxin, cortisol, sex hormone, growth hormone and D-vitamin-binding globulin concentrations in circulation are decreased after AAS administration. Alterations in carrier protein concentration levels may increase biologically active steroid concentrations. One could also hypothesize that AAS-mediated anabolism could be partly due to increased concentrations of circulating biologically active human growth hormone (GH) and insulin like growth factor-I (IGF-I), particularly when supraphysiological doses are used . Alén et al. (1987) found 5 to 60 times higher serum GH concentrations in subjects on AAS, even without concomitant use of exogenous GH. Local stimulation of IGF-I may be required in the process of anabolic action. Androgens are known to be needed in local production of IGF-I within the skeletal muscle. These could partly explain the mechanism of action of supraphysiological doses of AAS. On the other hand, these endings might also provide an explanation for the unpredictable adverse effects of AAS.
Anabolic androgenic steroids have established their usefulness in treating various types of anaemia, osteoporosis, androgen replacement therapy, muscle-wasting conditions, cachexia caused by various cancers, and HIV infection. Long-standing hypogonadism in adult males is associated with reduced bone remodelling and decreased bone formation. In treating muscle-wasting disorders with AAS, none of AAS preparations has proved to be superior to another. Recently, AAS have been studied for male andropause replacement therapy, but more studies are required before AAS can be used broadly for improving the
quality of life of ageing males.
To strengthen the anabolic properties of testosterone, more than 100 synthetic steroid derivatives have been described for human purposes. The anabolic effect promotes protein synthesis, muscle growth and erythropoiesis. In clinical practice, substances with anabolic effect are needed to overcome various catabolic states. However, none of these compounds are devoid of androgenicity. Androgenic and anabolic properties of anabolic steroids cannot be totally separated. Therefore, it is more appropriate to use the term anabolic androgenic steroids (AAS).Read More »
Testosterone Enanthate and Dbol cycle is consdered not only a steroid cycle for beginners but it can be used also by advanced athletes too, however dosages differ. This steroid cycle is good for gaining muscle mass and strength and in combination with hard training and diet high in protein will bring you very good results.Read More »
Some bodybuilders combine or "stack" anabolic steroids with other drugs. Other steroid users may "pyramid" or "cycle" their steroid doses, starting with a low dose of stacked drugs and then periodically increasing and decreasing the dosage of the steroid, it's possible that a person who stacks or cycles steroids can take a deadly combination.Read More »